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Simultaneous estimation of antidiabetic drugs by HPLC: Determination of Metformin HCl, Pioglitazone HCl, and Glimepiride using Reverse Phase Liquid Chromatography

Mr.Maulikkumar Amin, Mr.Deepak Kumar Jain, Dr Deepti Jain




[PDF.fs00] Simultaneous estimation of antidiabetic drugs by HPLC: Determination of Metformin HCl, Pioglitazone HCl, and Glimepiride using Reverse Phase Liquid Chromatography

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 |  2011-08-29 | Original language:English | PDF # 1 |  8.66 x.27 x5.91l,.40 | File type: PDF | 116 pages

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A simple, precise, rapid, and reproducible reversed-phase high-performance liquid chromatography method is developed for the simultaneous estimation of metformin hydrochloride (MET), pioglitazone hydrochloride (PIO), and glimepiride (GLP) present in multicomponent dosage forms. Chromatography is carried out isocratically at 25 degrees C 0.5 degrees C on an Inertsil-ODS-3 (C-18) Column (250 x 4.60 mm, 5 microm) with a mobile phase composed of methanol-phosphate buffer (pH...

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